Pyroluria, also referred to as kryptopyrroles or pyrroles, is a biochemical imbalance in the body, causing a build up of pyrroles, which are waste products produced by the breakdown of haemoglobin. Haemoglobin is the oxygen-carrying protein within red blood cells.

Everyone makes pyrroles, however some people produce excessive amounts of pyrroles which can be a problem as these pyrroles bind and inhibit the utilisation of zinc, Vitamin B6, biotin and Gamma-Linoleic-Acid (GLA).

Inadequate amounts of zinc and B6 will disrupt the methylation pathways (important for those with MTHFR) (you can read about the implications of disrupted methylation here). Inadequate B6 can lead to a build up of oxalic acid (or oxalate) in certain people (you can read about the implications of high oxalic acid here).

Elevated pyrroles causes oxidative stress and damage to cells, including nerves, resulting in disrupted chemical messaging in the brain. This can become a vicious cycle as the nutrients you are deplete in are very important in allowing the body to reduce oxidative stress and repair damaged cells. It is also very important to correct any methylation pathway (MTHR) issues, as this is essential for reducing oxidative stress.


Signs & Symptoms

Mental Health including depression, anxiety, poor concentration, brain fog, low stress tolerance.

Digestive issues including bloating, pain, nausea, diarrhoea, constipation, lack of appetite.

Autism spectrum disorders


Food intolerances

Skin conditions including eczema and acne.

Hormonal conditions including heavy periods, painful periods, irregular periods, PCOS, PMS, infertility.

Build up of oxalate causing joint pain, fibromyalgia, recurrent urinary tract infections, bladder pain, vulvodynia, chronic fatigue, gut pain, chronic candida, kidney stones.

Methylation cycle issues.

Nutrient deficiencies including zinc, Vitamin B6, biotin, GLA, iron, vitamin C, vitamin E, magnesium and manganese.


Pyroluria is triggered and exacerbated by many external factors including stress, leaky gut, infections including candida, heavy metal toxicity, genetic oxalic acid issues, over consumption of oxalate or methylation cycle (MTHFR) issues. Joanne will work with you to uncover the cause of your pyrroles, and create a treatment plan to address these causes and correct any nutrient deficiencies.

Appointments can be made online, or by emailing Joanne at  or by phone on 0400 658 003.

Online bookings  


Sydney Naturopath, Joanne Kennedy is available to assist with pyroluria and methylation cycle issues. For appointments please email Joanne at or call 0400 658 003.