Is Histamine Inflammatory? Understanding the Role of Histamine in Inflammation



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Is Histamine Inflammatory? Understanding the Role of Histamine in Inflammation


Histamine, a compound released from mast cells and basophils, plays a crucial role in the body’s inflammatory processes. In this blog post, we will explore the relationship between histamine and inflammation, discussing how histamine can contribute to chronic inflammation when imbalanced. We will also delve into the impact of histamine-containing foods and estrogen on histamine release, highlighting the importance of identifying and addressing the underlying causes of chronic histamine release and inflammation.

Histamine and Inflammation

Histamine is known for its vasodilatory properties, which are essential for the body’s inflammatory response. When histamine is released, it causes the widening of blood vessels, aiding in the delivery of immune cells and necessary resources to damaged tissues. This vascular expansion is an integral part of the body’s defense mechanism against infections and promotes tissue repair.

Histamine-Containing Foods and Inflammation

In addition to histamine release from mast cells, certain foods also contain histamine. When consumed, these foods can contribute to an increased histamine load in the body, leading to further vasodilation and inflammation. Examples of histamine-rich foods include fermented foods, aged cheeses, cured meats, tomatoes, spinach, eggplants, and tinned fish. For individuals with histamine intolerance or sensitivity, consuming these foods can worsen symptoms and perpetuate chronic inflammation.

Estrogen and Histamine Release

Estrogen, a hormone prevalent in both men and women, can stimulate mast cells to release histamine. This can lead to increased vasodilation and inflammation, particularly during certain hormonal fluctuations. Many women experience symptoms of high histamine and inflammation, such as headaches, migraines, bloating, fluid retention, acne, and insomnia, during ovulation when estrogen levels peak or premenstrually when progesterone drops. The imbalance between estrogen and progesterone can exacerbate histamine-related symptoms.

Chronic Histamine Release and Inflammation

When the underlying causes of histamine release, such as infections or tissue damage, are not identified and treated, chronic histamine release and inflammation can occur. This persistent inflammatory state can give rise to various health issues, including chronic skin disorders (hives, eczema, rosacea, acne), body and joint pain, chronic fatigue, headaches, gut issues (constipation, diarrhea, nausea, reflux, heartburn), anxiety, depression, insomnia, mast cell activation syndrome, chronic inflammatory response syndrome, cardiovascular disease, metabolic syndrome, and osteoporosis.


Histamine is indeed inflammatory, playing a crucial role in the body’s immune response and inflammatory processes. Understanding the connection between histamine and inflammation is essential for managing chronic health issues associated with histamine imbalance. By addressing the underlying causes, such as infections, tissue damage, histamine-rich foods, and hormonal imbalances, we can aim to reduce chronic histamine release and inflammation. Seeking professional guidance, adopting an anti-inflammatory diet, managing stress, and optimizing hormone balance can all contribute to better histamine regulation and overall well-being.


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Calvielli AC et al, 2018, ‘Role of Histamine in Modulating the Immune Response and Inflammation’, Mediators of Inflammation, vol. 2018, pp1-1.

Bodis J et al, 1993, ‘The effect of histamine on progesterone and estradiol secretion of human granulosa cells in serum-free culture’ Gynecological Endocrinology, vol. 7, no. 4

Fogel WA, 1986, ‘Diamine oxidase (DAO) and female sex hormones’, Agents & Actions, vol 18, no. 1-2

Zierau O, Zenclussen A & Jensen F, 2012 ‘Role of female sex hormones, estradiol and progesterone, in mast cell behavior’, Frontiers in Immunology, vol 19, no. 3.




This article is meant for informational purposes only and should not be considered a substitute for professional medical advice.

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