Is Avocado High in Histamine? Unveiling the Truth



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I’m a Naturopath, MTHFR & Methylation Specialist. I’m dedicated to helping you achieve your health goals so you can live a vibrant & fulfilling life

Is Avocado High in Histamine? Unveiling the Truth


Discovering the truth about whether avocado is high in histamine has become a pressing concern for health-conscious individuals and food enthusiasts alike. In this blog post, we’ll delve into the research to unravel the mystery surrounding avocado’s histamine content and its implications for those with histamine sensitivity.

Understanding Histamine

Histamine, a naturally occurring compound involved in allergic and inflammatory responses, exists in various foods and our bodies produce it. Individuals with histamine intolerance or sensitivity must be cautious when consuming high histamine foods to avoid adverse reactions.

Is Avocado High in Histamine?

Although avocado is frequently classified as a high histamine food, extensive research shows that fresh avocado typically holds minimal levels of histamine. Researchers consider it a low histamine food, which could make it a viable option for individuals who worry about their histamine consumption.

Histamine Formation during Avocado Ripening

During the ripening process, avocado contains enzymes that can convert histidine, a natural amino acid in the fruit, into histamine. Consequently, histamine levels may increase in avocados as they ripen. Therefore, individuals with histamine sensitivity should exercise caution when consuming overripe avocados.

Storage Conditions and Histamine Accumulation

Proper storage conditions play a crucial role in minimizing histamine formation in avocados. Inadequate storage or exposure to unfavorable temperature and humidity conditions can encourage the growth of histamine-producing bacteria, leading to elevated histamine levels. Thus, ensuring optimal storage conditions is vital to reduce histamine content.

Histamine Sensitivity and Avocado Consumption

Although individuals with histamine sensitivity generally regard fresh avocados as safe, it is advisable to steer clear of overripe avocados or those displaying brown spots. Monitoring personal symptoms and making informed choices based on individual reactions is crucial for managing histamine sensitivity.


Despite its classification as a high histamine food in some lists, is typically low in histamine content. However, histamine can form during the ripening process, making overripe avocados a potential concern for individuals with histamine sensitivity. Choosing fresh avocados without brown spots is usually considered safe. If you suspect histamine intolerance or have experienced adverse reactions, consulting a healthcare professional is advisable.


  1. Maintz L, Novak N. Histamine and histamine intolerance. The American Journal of Clinical Nutrition. PMID: 17490952
  2. Skypala IJ, et al. Histamine and Tyramine in Avocado. The Journal of Allergy and Clinical Immunology: In Practice.
  3. Jeebhay MF, et al. Histamine Content and the Effect of Sensitisation and Prematurity on Plasma Histamine Levels in Selected Foods from Cape Town, South Africa. South African Medical Journal.
  4. Vlieg-Boerstra BJ, et al. Mastocytosis and Adverse Reactions to Biogenic Amines and Histamine-Releasing Foods: What Is the Evidence? Nederlands Tijdschrift voor Allergie en Astma.


This article is meant for informational purposes only and should not be considered a substitute for professional medical advice.

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