Is Almond Butter Low in Histamine? Unraveling the Truth



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 Is Almond Butter Low in Histamine? Unraveling the Truth


Concerns about the histamine content and potential implications for individuals with histamine intolerance have arisen as almond butter gains popularity as a nutritious and versatile spread. In this blog post, we will delve into the research to determine whether almond butter is truly low in histamine. Let’s separate fact from fiction and shed light on the topic of almond butter and histamine.

Understanding Histamine

Histamine is a naturally occurring compound involved in allergic and inflammatory responses in the body. For individuals with histamine intolerance, managing histamine intake is crucial to avoid potential adverse reactions.

The Histamine Potential of Almond Butter

While almonds themselves generally have low histamine levels, certain factors that may increase histamine levels can pose challenges for individuals with histamine sensitivity when consuming almond butter.

Histamine Liberators and DAO Inhibition

Almonds contain substances that can act as histamine liberators and DAO inhibitors. Histamine liberators have the ability to trigger histamine release in the body, while DAO inhibitors hinder the degradation of histamine, leading to increased histamine levels in sensitive individuals.

Biogenic Amines and Almond Butter​

Nuts, including almonds, contain biogenic amines such as tyramine, which have the potential to induce histamine responses in susceptible individuals. The DAO enzyme prioritizes the breakdown of these amines over histamine, resulting in higher histamine levels. Prolonged storage of nuts may also contribute to increased biogenic amine content in almond butter.

Oxalates and Histamine Reactions

Almonds are naturally high in oxalates, sharp crystals that can cause tissue damage and trigger histamine release from mast cells. This histamine release can lead to various symptoms, including flushing, itching, heart palpitations, gut and bladder pain, anxiety, nausea, reflux, and headaches.

Salicylates and Adverse Reactions

Almonds are rich in salicylates, naturally occurring compounds found in many plants. Ingesting salicylates can elicit adverse reactions in certain individuals, particularly those with gut inflammation, liver detoxification impairment, poor kidney function, or metabolic acidosis. Symptoms may include rashes, itching, swelling, headaches, stomach cramps, diarrhea, and difficulty breathing.

Considerations for Individuals

While almonds themselves are generally low in histamine, individuals with histamine intolerance should exercise caution when consuming almond butter. The histamine-liberating and DAO-inhibiting properties, along with the presence of biogenic amines, oxalates, and salicylates, may affect individuals with histamine sensitivity differently. It is recommended to personally observe and consult with a healthcare professional.


While almonds are generally considered low in histamine, individuals with histamine intolerance should take into account certain factors presented by almond butter that can contribute to histamine-related concerns. This includes considering the presence of histamine liberators, DAO inhibitors, biogenic amines, oxalates, and salicylates. Understanding one’s own sensitivities and seeking professional advice can help navigate the consumption of almond butter.


  1. Maintz L, Novak N. Histamine and histamine intolerance. The American Journal of Clinical Nutrition. PMID: 17490952
  2. Swain AR, et al. Salicylates, oligoantigenic diets, and behavior. The Lancet. PMID: 2861485
  3. Boyce JA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. The Journal of Allergy and Clinical Immunology. PMID: 21134576
  4. Singh M, et al. Oxalate Content of Foods and Its Effect on Humans. Asia Pacific Journal of Clinical Nutrition PMID: 24393738


This article is meant for informational purposes only and should not be considered a substitute for professional medical advice.

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