Histamine Intolerance & eczema



I'm Joanne
I’m a Naturopath, MTHFR & Methylation Specialist. I’m dedicated to helping you achieve your health goals so you can live a vibrant & fulfilling life

Histamine Intolerance & eczema


La Jolla Institute researchers in California have unveiled that histamine release from mast cells is a key eczema trigger in humans.

We have long understood that eczema is an immunological condition, whereby the skin becomes inflamed due to various triggers. When the body senses triggers, it releases inflammatory cytokines and histamine to combat the threat. For some people, their ability to deal with this increase in histamine is compromised, leading to eczema.

What can trigger the release of histamine?

Small Intestinal Bacterial Overgrowth, leads to inflammation and histamine release.

Large bowel gut bacteria

An overgrowth of unwanted bacteria in the gut such as Klebsiella or Citrobacter will release histamine. While your gut might be fine, eczema can still develop on your skin due to this.


Whether from infection, parasites, viruses, or autoimmune conditions, triggers mast cells to release histamine, leading to eczema.


Unfortunately for women (and some men), oestrogen can stimulate the release of histamine. This often occurs in women with estrogen dominance who struggle to effectively clear estrogen via the liver.  This is common in women with MTHFR and COMT gene mutations.


Releases CRH from both adrenal glands and skin.. Therefore, CRH is stimulating mast cells to release histamine directly on the skin causing eczema.


Fermented items (soy, miso, kimchi, sauerkraut), aged cheeses, alcohol, yeast, shellfish, canned tuna, processed meats, chocolate, and tomatoes can raise body histamine.

This is a big issue. If you have mould in your house this may be the major cause of your eczema.  Mould is toxic to the immune system and will cause havoc with histamine. Feeling better away from home suggests potential hidden mold presence.

Why am I more susceptible to histamine and eczema than other people?

People with MTHFR and methylation cycle issues can have issues breaking down histamine via the HNMT enzyme

DAO gene mutation

DAO gene mutation leads to continuous release of the DAO enzyme from the gut’s mucosa to eliminate excess histamine. A mutation in the gene leads to a reduction in functioning of this enzyme.

Chronic gut problems, multiple antibiotics, reflux meds, prolonged IBS, and food intolerances reduce gut DAO activity.

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