Does Magnesium Lower Histamine Levels? Exploring the Connection



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I’m a Naturopath, MTHFR & Methylation Specialist. I’m dedicated to helping you achieve your health goals so you can live a vibrant & fulfilling life

Does Magnesium Lower Histamine Levels? Exploring the Connection


When it comes to histamine regulation in the body, magnesium plays a crucial role. In this blog post, we will delve into the question: Does magnesium lower histamine levels? Understanding this connection is essential for individuals seeking to manage histamine-related symptoms effectively. We’ll explore how magnesium influences histamine breakdown, the impact of magnesium deficiency on mast cell activation, and the signs of magnesium deficiency to watch out for. Additionally, we’ll provide a list of magnesium-rich foods that are low in histamine and discuss magnesium supplementation options.

Magnesium's Role in Histamine Breakdown

Magnesium is an important component in the production of SAMe (S-adenosylmethionine), a major methyl donor in the body. SAMe is responsible for breaking down histamine through the Histamine-N-Methyltransferase enzyme present in various organs, including the kidney, liver, spleen, colon, prostate, ovary, spinal cord, bronchi, trachea, and brain. Adequate magnesium levels are necessary to support the production of SAMe and facilitate histamine breakdown.

Magnesium Deficiency and Mast Cell Activation

Animal studies have shown that magnesium deficiency can increase mast cell activation, particularly in the small intestine, kidney, bone marrow, and liver. Mast cells are immune cells that release histamine in response to threats like infection or injury. Interestingly, estrogen can also stimulate mast cells to release histamine. Therefore, maintaining sufficient magnesium levels is crucial to prevent excessive mast cell activation and subsequent histamine release.

Inflammation and Magnesium Deficiency​

Magnesium deficiency can contribute to inflammation, which in turn stimulates mast cells to release histamine. To avoid histamine-related issues, it is important to ensure an adequate intake of magnesium. Signs of magnesium deficiency include muscle cramps, muscle twitches, anxiety, premenstrual syndrome, disturbed sleep, addictions, agitation, irritability, headaches, irregular heartbeat, high blood pressure, insulin resistance, kidney stones, and osteoporosis.

Factors Affecting Magnesium Demand

Several factors can increase the demand for magnesium in the body. These include alcohol consumption, caffeine consumption, high red meat consumption, oral contraceptive pill usage, thyroxine medication, and certain medications like antibiotics, prednisone, and hydrocortisone. Additionally, supplementing with calcium, Vitamin B1, Vitamin B6, Vitamin C, and Vitamin E can also increase the need for magnesium.

Magnesium-Rich Foods Low in Histamine

For individuals looking to increase their magnesium intake while keeping histamine levels in check, incorporating magnesium-rich foods low in histamine into their diet is a great strategy. Some examples of such foods high in magnesium and low in histamine include fresh almonds, and brazil nuts, pumpkin seeds, flaxseeds, sunflower seeds, fresh cod, eggs, figs, swiss chard, collard greens, kale, snow peas, broccoli, zucchini, green beans, brussel sprouts, asparagus, and parsnip.

Supplementing with Magnesium

If you need to quickly raise your magnesium levels, supplementation can be an option. It is generally recommended to supplement with 300-400mg of magnesium per day. However, it’s important to consult with a healthcare professional to determine the appropriate dosage and form of magnesium for your specific needs.


Magnesium plays a vital role in histamine regulation and breakdown in the body. Maintaining adequate magnesium levels is essential for preventing histamine-related symptoms and managing conditions associated with excessive histamine release. By incorporating magnesium-rich foods and, if necessary, supplementation, individuals can support their overall health and well-being while addressing histamine imbalances.


This article is meant for informational purposes only and should not be considered a substitute for professional medical advice.

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