MTHFR is a key gene in methylation. Methylation is a major pathway in phase 2 liver detoxification of oestrogen. Issues with the methylation pathway can lead to reduced methylation of oestrogen causing a build up of unwanted oestrogens and symptoms of oestrogen dominance.
There are so many links between MTHFR and histamine intolerance that it deserves it own blog post. I’ve broken it all down for you step by step.
The link between histamine and oestrogen is very interesting and extremely important to understand when treating women’s hormonal conditions.
SIBO is a major cause of histamine intolerance. In SIBO the DAO enzyme that degrades histamine in the gut gets overloaded with histamine causing many symptoms including headaches, itchy skin, flushing, reflux and much more.